"Cherokee Medicine, Colonial Germs"

Cherokee Medicine, Colonial Germs: An Indigenous Nation's Fight against Smallpox, 1518-1824 is written by Paul Kelton, professor of American History at Stony Brook University, and covers the nuanced history of Variola among American Indians.  The research shows a history more complex than you may recall from high school history class.
 

Published by the University of Oklahoma Press, paperback